A Review of Zoloft Common Side Effects


When taking Zoloft common side effects may occur. Clinical trials were conducted before the product was made available to the public. Prizer, the manufacturer of Zoloft, administered the medication to over 4000 adults back in the year 2000. There was a mixture of how long they took the drug and what they were being treated for such as depression, OCD, PTSD and so on. So, it was a good representative sample of the general population that would be taking the medication. The studies also varied by structure such as controlled, uncontrolled, in-patient, out-patient, double blind and so on. So, without boring you with all the technical details, let’s get to the side effects of taking Zoloft medications.



In the results below, I will categorize the side effects by most common, moderate and less common. Also, I will focus on only the participants that took the Zoloft (2,799 of them) versus the participants that took the placebo. In my opinion, this is most relevant.

Most Common Side Effects

  • Ejaculation difficulties (in men) (14%)
  • Dry mouth (14%)
  • Dizziness (12%)
  • Headache (25%)
  • Diarrhea (20%)
  • Nausea (25%)
  • Fatigue (12%)
  • Insomnia (21%)

    Moderate Side Effects

  • Increased perspiration (7%)
  • Tremors (8%)
  • Constipation (6%)
  • Digestive issues (8%)
  • Decreased libido (6%)

    Less Common Side Effects

  • Abnormal prickling or itching (2%)
  • Rash (3%)
  • Vomiting (4%)
  • Agitation (5%)
  • Anxiety (4%)
  • Nervousness (5%)
  • Abnormal vision (3%)

    So, as with all medications, Zoloft common side effects should be carefully considered when deciding if this is the medication that you choose to treat your condition.


    There are also some Zoloft withdrawal symptoms that can be experienced once you decide to stop taking the drug. Inspite of the side effects and withdrawal symptoms, Zoloft antidepressant is a good one to take. Many people ask me about Zoloft in pregnancy and Zoloft and breast feeding. In fact, OB’s like to prescribe this medication to nursing mothers at it has little to no impact on the infant. However, it should be carefully considered if you are pregnant or you might get pregnant.

    Photos courtesy of 123RF.com

    Zoloft Common Side Effects to Depression Test Home Page


  • Happy family after overcoming depression- Depression Test



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